Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney diseas...
Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other organs. Human kidney organoids can reconstitute PKD cystogenesis in a genetically specific way, but the mechanisms underlying cystogenesis remain elusive. Here we show that subjecting organoids to fluid shear stress in a PKD-on-a-chip microphysiological s...
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Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease
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TN_cdi_doaj_primary_oai_doaj_org_article_c46ae4379a784182858157d336548bc7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c46ae4379a784182858157d336548bc7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35537-2
