Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-act...
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for an...
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Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
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TN_cdi_doaj_primary_oai_doaj_org_article_c495829fb81244ae9a98fa22e7548c0d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c495829fb81244ae9a98fa22e7548c0d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05906-x
