Progranulin deficiency in Iba-1 + myeloid cells exacerbates choroidal neovascularization by perturba...
Progranulin deficiency in Iba-1 + myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and plays an important role in controlling the lysosomal function....
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Progranulin deficiency in Iba-1 + myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation
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TN_cdi_doaj_primary_oai_doaj_org_article_c66eabbd3f5e430cb87178ce4cb60efb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c66eabbd3f5e430cb87178ce4cb60efb
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-021-02203-1
