The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Sh...
The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Short Double-Stranded Immunostimulating RNA
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
A short 19 bp dsRNA with 3'-trinucleotide overhangs acting as immunostimulating RNA (isRNA) demonstrated strong antiproliferative action against cancer cells, immunostimulatory activity through activation of cytokines and Type-I IFN secretion, as well as anti-tumor and anti-metastatic effects in vivo. The aim of this study was to determine the tole...
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Full title
The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Short Double-Stranded Immunostimulating RNA
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TN_cdi_doaj_primary_oai_doaj_org_article_c6aabba104144e50b02e58a6ee79e1f2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c6aabba104144e50b02e58a6ee79e1f2
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules29133225
