A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
About this item
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Author / Creator
Li, Li , Ugalde, Alejandro P. , Scheele, Colinda L. G. J. , Dieter, Sebastian M. , Nagel, Remco , Ma, Jin , Pataskar, Abhijeet , Korkmaz, Gozde , Elkon, Ran , Chien, Miao-Ping , You, Li , Su, Pin-Rui , Bleijerveld, Onno B. , Altelaar, Maarten , Momchev, Lyubomir , Manber, Zohar , Han, Ruiqi , van Breugel, Pieter C. , Lopes, Rui , ten Dijke, Peter , van Rheenen, Jacco and Agami, Reuven
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thousands of YAP/TEAD4 binding-sites are annotated, their functional importance is unknown. Here, we aim at further identific...
Alternative Titles
Full title
A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Authors, Artists and Contributors
Author / Creator
Ugalde, Alejandro P.
Scheele, Colinda L. G. J.
Dieter, Sebastian M.
Nagel, Remco
Ma, Jin
Pataskar, Abhijeet
Korkmaz, Gozde
Elkon, Ran
Chien, Miao-Ping
You, Li
Su, Pin-Rui
Bleijerveld, Onno B.
Altelaar, Maarten
Momchev, Lyubomir
Manber, Zohar
Han, Ruiqi
van Breugel, Pieter C.
Lopes, Rui
ten Dijke, Peter
van Rheenen, Jacco
Agami, Reuven
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c775eb768cb945179e71e99f571ae872
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c775eb768cb945179e71e99f571ae872
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02272-8
