Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
About this item
Full title
Author / Creator
Graff, Rebecca E. , Cavazos, Taylor B. , Thai, Khanh K. , Kachuri, Linda , Rashkin, Sara R. , Hoffman, Joshua D. , Alexeeff, Stacey E. , Blatchins, Maruta , Meyers, Travis J. , Leong, Lancelote , Tai, Caroline G. , Emami, Nima C. , Corley, Douglas A. , Kushi, Lawrence H. , Ziv, Elad , Van Den Eeden, Stephen K. , Jorgenson, Eric , Hoffmann, Thomas J. , Habel, Laurel A. , Witte, John S. and Sakoda, Lori C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969 cases, 359,802 controls). Within cohorts, each PR...
Alternative Titles
Full title
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
Authors, Artists and Contributors
Author / Creator
Cavazos, Taylor B.
Thai, Khanh K.
Kachuri, Linda
Rashkin, Sara R.
Hoffman, Joshua D.
Alexeeff, Stacey E.
Blatchins, Maruta
Meyers, Travis J.
Leong, Lancelote
Tai, Caroline G.
Emami, Nima C.
Corley, Douglas A.
Kushi, Lawrence H.
Ziv, Elad
Van Den Eeden, Stephen K.
Jorgenson, Eric
Hoffmann, Thomas J.
Habel, Laurel A.
Witte, John S.
Sakoda, Lori C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c8c7f06feddc43b4892e0628726c8ee8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c8c7f06feddc43b4892e0628726c8ee8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21288-z
