Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
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Author / Creator
Formisano, Luigi , Lu, Yao , Servetto, Alberto , Hanker, Ariella B. , Jansen, Valerie M. , Bauer, Joshua A. , Sudhan, Dhivya R. , Guerrero-Zotano, Angel L. , Croessmann, Sarah , Guo, Yan , Ericsson, Paula Gonzalez , Lee, Kyung-min , Nixon, Mellissa J. , Schwarz, Luis J. , Sanders, Melinda E. , Dugger, Teresa C. , Cruz, Marcelo Rocha , Behdad, Amir , Cristofanilli, Massimo , Bardia, Aditya , O’Shaughnessy, Joyce , Nagy, Rebecca J. , Lanman, Richard B. , Solovieff, Nadia , He, Wei , Miller, Michelle , Su, Fei , Shyr, Yu , Mayer, Ingrid A. , Balko, Justin M. and Arteaga, Carlos L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant ± ribociclib or palbociclib. This resistance was abrogated by treatment with the F...
Alternative Titles
Full title
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
Authors, Artists and Contributors
Author / Creator
Lu, Yao
Servetto, Alberto
Hanker, Ariella B.
Jansen, Valerie M.
Bauer, Joshua A.
Sudhan, Dhivya R.
Guerrero-Zotano, Angel L.
Croessmann, Sarah
Guo, Yan
Ericsson, Paula Gonzalez
Lee, Kyung-min
Nixon, Mellissa J.
Schwarz, Luis J.
Sanders, Melinda E.
Dugger, Teresa C.
Cruz, Marcelo Rocha
Behdad, Amir
Cristofanilli, Massimo
Bardia, Aditya
O’Shaughnessy, Joyce
Nagy, Rebecca J.
Lanman, Richard B.
Solovieff, Nadia
He, Wei
Miller, Michelle
Su, Fei
Shyr, Yu
Mayer, Ingrid A.
Balko, Justin M.
Arteaga, Carlos L.
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_c9a8bb9c2aac44dba476758c76c4a8d4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9a8bb9c2aac44dba476758c76c4a8d4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09068-2
