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Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9e161aeee0b4d8fb9c114a3126f6415

Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

About this item

Full title

Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2021-09, Vol.12 (1), p.5315-5315, Article 5315

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. We report that U2OS cells expressing PAK4-BirA-GFP identify a subset of 27 PAK4-proximal prote...

Alternative Titles

Full title

Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_c9e161aeee0b4d8fb9c114a3126f6415

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_c9e161aeee0b4d8fb9c114a3126f6415

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-021-25011-w

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