Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
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Author / Creator
Flønes, Irene H. , Toker, Lilah , Sandnes, Dagny Ann , Castelli, Martina , Mostafavi, Sepideh , Lura, Njål , Shadad, Omnia , Fernandez-Vizarra, Erika , Painous, Cèlia , Pérez-Soriano, Alexandra , Compta, Yaroslau , Molina-Porcel, Laura , Alves, Guido , Tysnes, Ole-Bjørn , Dölle, Christian , Nido, Gonzalo S. and Tzoulis, Charalampos
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory complex I (CI) deficiency, and identify two emerging disease subtypes with distinct molecular and clinical profi...
Alternative Titles
Full title
Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_ca1314f7e4514676b9bb0eefc96db530
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ca1314f7e4514676b9bb0eefc96db530
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47867-4
