Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leuke...
Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia
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England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unknown.
Using an inducible system, we comprehensively analyze the 3D genome organization in myeloid cells and its reorgani...
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Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_ca1f2e55568d425387ee866b9625748d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ca1f2e55568d425387ee866b9625748d
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-020-02030-2
