Absence of CX3CR1 impairs the internalization of Tau by microglia
Absence of CX3CR1 impairs the internalization of Tau by microglia
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism.
We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, affinity chromatography to study the binding of Tau to CX3CR1, and Ta...
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Full title
Absence of CX3CR1 impairs the internalization of Tau by microglia
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TN_cdi_doaj_primary_oai_doaj_org_article_cb2fab112be14c36a4efe1761104760f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cb2fab112be14c36a4efe1761104760f
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-017-0200-1
