Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palm...
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood. Here, we demonstrate that HFD increases palmitic acid deposition in the hippocampus and induces hippocampal insulin resistance leading to FoxO3a-mediated overexpression o...
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Full title
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
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TN_cdi_doaj_primary_oai_doaj_org_article_cb4640a300fa422e8b1d52b272e63d1d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cb4640a300fa422e8b1d52b272e63d1d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02221-9
