An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mutations and variations in and around
SCN5A
, encoding the major cardiac sodium channel, influence impulse conduction and are associated with a broad spectrum of arrhythmia disorders. Here, we identify an evolutionary conserved regulatory cluster with super enhancer characteristics downstream of
SCN5A
, which drives localized cardiac e...
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Full title
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_cb64f996f52046f4a1729c8c928335c9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cb64f996f52046f4a1729c8c928335c9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12856-5
