cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron...
cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types. 5hmC is converted from 5-methylcytosine (5mC) by Tet methylcytosine dioxygenases, for which Fe(II)...
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Full title
cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool
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TN_cdi_doaj_primary_oai_doaj_org_article_cb740e3e9cd14769a9739af54a035d72
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cb740e3e9cd14769a9739af54a035d72
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.29750
