Analysis of polygenic risk score usage and performance in diverse human populations
Analysis of polygenic risk score usage and performance in diverse human populations
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Author / Creator
Duncan, L. , Shen, H. , Gelaye, B. , Meijsen, J. , Ressler, K. , Feldman, M. , Peterson, R. and Domingue, B.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
A historical tendency to use European ancestry samples hinders medical genetics research, including the use of polygenic scores, which are individual-level metrics of genetic risk. We analyze the first decade of polygenic scoring studies (2008–2017, inclusive), and find that 67% of studies included exclusively European ancestry participants and ano...
Alternative Titles
Full title
Analysis of polygenic risk score usage and performance in diverse human populations
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TN_cdi_doaj_primary_oai_doaj_org_article_cb93a6b3791441d4a1f333febc9cc943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cb93a6b3791441d4a1f333febc9cc943
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11112-0
