A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3). Most of those ERVs, including IAPs, remain silent if
Setdb1
is deleted in differentiated embryonic cells; however they are derepressed when deficient for
Dnmt1
Alternative Titles
Full title
A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
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TN_cdi_doaj_primary_oai_doaj_org_article_cc0731fe6d5a4eed89c9169bcf9c60b8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc0731fe6d5a4eed89c9169bcf9c60b8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04132-9
