High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of...
High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing
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Author / Creator
Kostecka, Anna , Nowikiewicz, Tomasz , Olszewski, Paweł , Koczkowska, Magdalena , Horbacz, Monika , Heinzl, Monika , Andreou, Maria , Salazar, Renato , Mair, Theresa , Madanecki, Piotr , Gucwa, Magdalena , Davies, Hanna , Skokowski, Jarosław , Buckley, Patrick G. , Pęksa, Rafał , Śrutek, Ewa , Szylberg, Łukasz , Hartman, Johan , Jankowski, Michał , Zegarski, Wojciech , Tiemann-Boege, Irene , Dumanski, Jan P. and Piotrowski, Arkadiusz
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The mammary gland undergoes hormonally stimulated cycles of proliferation, lactation, and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population, and recurrent disease. Hence, we investigated the DNA sequence variants in the normal mammar...
Alternative Titles
Full title
High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing
Authors, Artists and Contributors
Author / Creator
Nowikiewicz, Tomasz
Olszewski, Paweł
Koczkowska, Magdalena
Horbacz, Monika
Heinzl, Monika
Andreou, Maria
Salazar, Renato
Mair, Theresa
Madanecki, Piotr
Gucwa, Magdalena
Davies, Hanna
Skokowski, Jarosław
Buckley, Patrick G.
Pęksa, Rafał
Śrutek, Ewa
Szylberg, Łukasz
Hartman, Johan
Jankowski, Michał
Zegarski, Wojciech
Tiemann-Boege, Irene
Dumanski, Jan P.
Piotrowski, Arkadiusz
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_cc2598149fc04588ac0c210c85b15585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc2598149fc04588ac0c210c85b15585
Other Identifiers
ISSN
2374-4677
E-ISSN
2374-4677
DOI
10.1038/s41523-022-00443-9
