Genetically engineered red cells expressing single domain camelid antibodies confer long-term protec...
Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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A short half-life in the circulation limits the application of therapeutics such as single-domain antibodies (VHHs). We utilize red blood cells to prolong the circulatory half-life of VHHs. Here we present VHHs against botulinum neurotoxin A (BoNT/A) on the surface of red blood cells by expressing chimeric proteins of VHHs with Glycophorin A or Kel...
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Full title
Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin
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TN_cdi_doaj_primary_oai_doaj_org_article_cc5b7658df0d48e1aa16746d22081aea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc5b7658df0d48e1aa16746d22081aea
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00448-0
