Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasi...
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
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Author / Creator
Deng, Yalan , Xia, Xianghou , Zhao, Yang , Zhao, Zilong , Martinez, Consuelo , Yin, Wenjuan , Yao, Jun , Hang, Qinglei , Wu, Weiche , Zhang, Jie , Yu, Yang , Xia, Weiya , Yao, Fan , Zhao, Di , Sun, Yutong , Ying, Haoqiang , Hung, Mien-Chie and Ma, Li
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Despite unprecedented responses of some cancers to immune checkpoint blockade (ICB) therapies, the application of checkpoint inhibitors in pancreatic cancer has been unsuccessful. Glucocorticoids and glucocorticoid receptor (GR) signaling are long thought to suppress immunity by acting on immune cells. Here we demonstrate a previously undescribed t...
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Full title
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
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TN_cdi_doaj_primary_oai_doaj_org_article_cd101d5af69a4e4fb8c3d297b2fc29f8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cd101d5af69a4e4fb8c3d297b2fc29f8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27349-7
