The binding and mechanism of a positive allosteric modulator of Kv3 channels
The binding and mechanism of a positive allosteric modulator of Kv3 channels
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Small-molecule modulators of diverse voltage-gated K
+
(Kv) channels may help treat a wide range of neurological disorders. However, developing effective modulators requires understanding of their mechanism of action. We apply an orthogonal approach to elucidate the mechanism of action of an imidazolidinedione derivative (AUT5), a highly sele...
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Full title
The binding and mechanism of a positive allosteric modulator of Kv3 channels
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TN_cdi_doaj_primary_oai_doaj_org_article_cd3c8dd7577c4ee08657c1ab9f7f472d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cd3c8dd7577c4ee08657c1ab9f7f472d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46813-8
