Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting
Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Eukaryotic mRNAs are transcribed, processed, translated, and degraded in different subcellular compartments. Here, we measured mRNA flow rates between subcellular compartments in mouse embryonic stem cells. By combining metabolic RNA labeling, biochemical fractionation, mRNA sequencing, and mathematical modeling, we determined the half-lives of nuc...
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Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting
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TN_cdi_doaj_primary_oai_doaj_org_article_cd7c93d9d05f417aa8db01cc22735a54
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cd7c93d9d05f417aa8db01cc22735a54
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ISSN
1744-4292
E-ISSN
1744-4292
DOI
10.1038/s44320-024-00073-2
