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A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d0e2578f1c324ddc8a46d5d697abf0e7

A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

About this item

Full title

A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2021-06, Vol.11 (1), p.11996-11996, Article 11996

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from virus or self-DNA from mitochondria/nuclei. In response to emergence of such DNAs in the cytosol, STING translocates from the endoplasmic reticulum to the Golgi, and activates TANK-binding kinase 1 (TBK1) at the trans-Golgi network (...

Alternative Titles

Full title

A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_d0e2578f1c324ddc8a46d5d697abf0e7

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d0e2578f1c324ddc8a46d5d697abf0e7

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-021-91562-z

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