A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from virus or self-DNA from mitochondria/nuclei. In response to emergence of such DNAs in the cytosol, STING translocates from the endoplasmic reticulum to the Golgi, and activates TANK-binding kinase 1 (TBK1) at the trans-Golgi network (...
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A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation
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TN_cdi_doaj_primary_oai_doaj_org_article_d0e2578f1c324ddc8a46d5d697abf0e7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d0e2578f1c324ddc8a46d5d697abf0e7
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2045-2322
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2045-2322
DOI
10.1038/s41598-021-91562-z