Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
About this item
Full title
Author / Creator
Wurm, Alexander Arthur , Zjablovskaja, Polina , Kardosova, Miroslava , Gerloff, Dennis , Bräuer-Hartmann, Daniela , Katzerke, Christiane , Hartmann, Jens-Uwe , Benoukraf, Touati , Fricke, Stephan , Hilger, Nadja , Müller, Anne-Marie , Bill, Marius , Schwind, Sebastian , Tenen, Daniel G. , Niederwieser, Dietger , Alberich-Jorda, Meritxell and Behre, Gerhard
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Transcription factor C/EBPα is a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia. Deregulation of C/EBPα by microRNAs during granulopoiesis or acute myeloid leukemia development has not been studied. Here we show that oncogenic miR-182 is a strong regulator of C/EBPα. Moreover, we identify a regulator...
Alternative Titles
Full title
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
Authors, Artists and Contributors
Author / Creator
Zjablovskaja, Polina
Kardosova, Miroslava
Gerloff, Dennis
Bräuer-Hartmann, Daniela
Katzerke, Christiane
Hartmann, Jens-Uwe
Benoukraf, Touati
Fricke, Stephan
Hilger, Nadja
Müller, Anne-Marie
Bill, Marius
Schwind, Sebastian
Tenen, Daniel G.
Niederwieser, Dietger
Alberich-Jorda, Meritxell
Behre, Gerhard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d1070167e8204aeba7d47363aee0bb8f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d1070167e8204aeba7d47363aee0bb8f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00032-6
