Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, am...
Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice
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Author / Creator
He, Lujuan , Zheng, Yi , Huang, Lixuan , Ye, Jingyi , Ye, Yinyi , Luo, Hanyue , Chen, Xi , Yao, Wei , Chen, Jiaxu and Zhang, Ji-chun
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice. However, the key molecular mechanism that mediates major depressive disorder (MDD) pathogenesis remains elusive. We herein show that Nrf2 regulates TREM2 transcription and e...
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Full title
Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_d173eb1bb6a940e083ff62faa61bab7a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d173eb1bb6a940e083ff62faa61bab7a
Other Identifiers
ISSN
2158-3188
E-ISSN
2158-3188
DOI
10.1038/s41398-022-02227-y
