Incomplete human reference genomes can drive false sex biases and expose patient-identifying informa...
Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data
About this item
Full title
Author / Creator
Guccione, Caitlin , Patel, Lucas , Tomofuji, Yoshihiko , McDonald, Daniel , Gonzalez, Antonio , Sepich-Poore, Gregory D. , Sonehara, Kyuto , Zakeri, Mohsen , Chen, Yang , Dilmore, Amanda Hazel , Damle, Neil , Baranzini, Sergio E. , Hightower, George , Nakatsuji, Teruaki , Gallo, Richard L. , Langmead, Ben , Okada, Yukinori , Curtius, Kit and Knight, Rob
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
As next-generation sequencing technologies produce deeper genome coverages at lower costs, there is a critical need for reliable computational host DNA removal in metagenomic data. We find that insufficient host filtration using prior human genome references can introduce false sex biases and inadvertently permit flow-through of host-specific DNA d...
Alternative Titles
Full title
Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data
Authors, Artists and Contributors
Author / Creator
Patel, Lucas
Tomofuji, Yoshihiko
McDonald, Daniel
Gonzalez, Antonio
Sepich-Poore, Gregory D.
Sonehara, Kyuto
Zakeri, Mohsen
Chen, Yang
Dilmore, Amanda Hazel
Damle, Neil
Baranzini, Sergio E.
Hightower, George
Nakatsuji, Teruaki
Gallo, Richard L.
Langmead, Ben
Okada, Yukinori
Curtius, Kit
Knight, Rob
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d1c6c644f8c845f18b85029b4687b675
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d1c6c644f8c845f18b85029b4687b675
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-56077-5
