Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism
Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER-positive breast cancer, but that at high doses kills both ER-positive and ER-negative breast cancer cells. We recapitulate this off-target effect in
Caenorhabditis elegans
, which does not have an ER ortholog. We find that different bacteria dramatically modula...
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Full title
Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism
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TN_cdi_doaj_primary_oai_doaj_org_article_d1e6384868304dae8858d56f74222a07
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d1e6384868304dae8858d56f74222a07
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33299-5
