Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibito...
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors. However, understanding the cellular role of VRKs and establishing their potential use as targets for therapeutic intervention has been limited by the lack...
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Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
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TN_cdi_doaj_primary_oai_doaj_org_article_d22a9c457cc045fe83ff71cae34b8e46
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d22a9c457cc045fe83ff71cae34b8e46
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-07755-y
