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ArticlesPeer ReviewedFull Text
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
Author / Creator:Racioppi, Luigi ; Nelson, Erik R. ; Huang, Wei ; Mukherjee, Debarati ; Lawrence, Scott A. ; Lento, William ; Masci, Anna Maria ; Jiao, Yiquin ; Park, Sunghee ; York, Brian ; Liu, Yaping ; Baek, Amy E. ; Drewry, David H. ; Zuercher, William J. ; Bertani, Francesca R. ; Businaro, Luca ; Geradts, Joseph ; Hall, Allison ; Means, Anthony R. ; Chao, Nelson ; Chang, Ching-yi ; McDonnell, Donald P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-06, Vol.10 (1), p.2450-2450, Article 2450
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Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
Author / Creator:Michalek, Ryan D ; Gerriets, Valerie A ; Nichols, Amanda G ; Inoue, Makoto ; Kazmin, Dmitri ; Chang, Ching-Yi ; Dwyer, Mary A ; Nelson, Erik R ; Pollizzi, Kristen N ; Ilkayeva, Olga ; Giguere, Vincent ; Zuercher, William J ; Powell, Jonathan D ; Shinohara, Mari L ; McDonnell, Donald P ; Rathmell, Jeffrey C
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.108 (45), p.18348-18353
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Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays
Author / Creator:Dranchak, Patricia ; MacArthur, Ryan ; Guha, Rajarshi ; Zuercher, William J. ; Drewry, David H. ; Auld, Douglas S. ; Inglese, James
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-03, Vol.8 (3), p.e57888-e57888
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Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline
Author / Creator:Volpatti, Jonathan R ; Endo, Yukari ; Knox, Jessica ; Groom, Linda ; Brennan, Stephanie ; Noche, Ramil ; Zuercher, William J ; Roy, Peter ; Dirksen, Robert T ; Dowling, James J
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-03, Vol.9
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New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)
Author / Creator:Asquith, Christopher R. M. ; Laitinen, Tuomo ; Wells, Carrow I. ; Tizzard, Graham J. ; Zuercher, William J.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-04, Vol.25 (7), p.1697
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In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds
Author / Creator:O’Byrne, Sean N. ; Scott, John W. ; Pilotte, Joseph R. ; Santiago, André da S. ; Langendorf, Christopher G. ; Oakhill, Jonathan S. ; Eduful, Benjamin J. ; Couñago, Rafael M. ; Wells, Carrow I. ; Zuercher, William J. ; Willson, Timothy M. ; Drewry, David H.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-01, Vol.25 (2), p.325
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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)
Author / Creator:Asquith, Christopher R. M. ; Bennett, James M. ; Su, Lianyong ; Laitinen, Tuomo ; Elkins, Jonathan M. ; Pickett, Julie E. ; Wells, Carrow I. ; Li, Zengbiao ; Willson, Timothy M. ; Zuercher, William J.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4016
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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors
Author / Creator:Asquith, Christopher R. M. ; Godoi, Paulo H. ; Couñago, Rafael M. ; Laitinen, Tuomo ; Scott, John W. ; Langendorf, Christopher G. ; Oakhill, Jonathan S. ; Drewry, David H. ; Zuercher, William J. ; Koutentis, Panayiotis A. ; Willson, Timothy M. ; Kalogirou, Andreas S.
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-05, Vol.23 (5), p.1221
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Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Author / Creator:Long, Thavy ; Neitz, R. Jeffrey ; Beasley, Rachel ; Kalyanaraman, Chakrapani ; Suzuki, Brian M. ; Jacobson, Matthew P. ; Dissous, Colette ; McKerrow, James H. ; Drewry, David H. ; Zuercher, William J. ; Singh, Rahul ; Caffrey, Conor R.
Publisher:United States: Public Library of Science
Journal title:PLoS neglected tropical diseases, 2016-01, Vol.10 (1), p.e0004356-e0004356
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Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data
Author / Creator:Strang, Blair L. ; Asquith, Christopher R. M. ; Moshrif, Hanan F. ; Ho, Catherine M-K ; Zuercher, William J. ; Al-Ali, Hassan
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-07, Vol.13 (7), p.e0201321-e0201321
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Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
Author / Creator:Couñago, Rafael M. ; Allerston, Charles K. ; Savitsky, Pavel ; Azevedo, Hatylas ; Godoi, Paulo H. ; Wells, Carrow I. ; Mascarello, Alessandra ; de Souza Gama, Fernando H. ; Massirer, Katlin B. ; Zuercher, William J. ; Guimarães, Cristiano R. W. ; Gileadi, Opher
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-08, Vol.7 (1), p.7501-12, Article 7501
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ArticlesPeer ReviewedFull Text
Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation
Author / Creator:Rahman, Atiqur ; Henry, Katherine M ; Herman, Kimberly D ; Thompson, Alfred AR ; Isles, Hannah M ; Tulotta, Claudia ; Sammut, David ; Rougeot, Julien JY ; Khoshaein, Nika ; Reese, Abigail E ; Higgins, Kathryn ; Tabor, Caroline ; Sabroe, Ian ; Zuercher, William J ; Savage, Caroline O ; Meijer, Annemarie H ; Whyte, Moira KB ; Dockrell, David H ; Renshaw, Stephen A ; Prince, Lynne R
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2019-10, Vol.8
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Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes
Author / Creator:Matossian, Margarite D. ; Elliott, Steven ; Hoang, Van T. ; Burks, Hope E. ; Phamduy, Theresa B. ; Chrisey, Douglas B. ; Zuercher, William J. ; Drewry, David H. ; Wells, Carrow ; Collins-Burow, Bridgette ; Burow, Matthew E.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-08, Vol.12 (8), p.e0177802-e0177802
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Kinase Inhibitor Screening Displayed ALK as a Possible Therapeutic Biomarker for Gastric Cancer
Author / Creator:Mesquita, Felipe Pantoja ; Souza, Pedro Filho Noronha ; da Silva, Emerson Lucena ; Lima, Luina Benevides ; de Oliveira, Lais Lacerda Brasil ; Moreira-Nunes, Caroline Aquino ; Zuercher, William J. ; Burbano, Rommel Mario Rodríguez ; de Moraes, Maria Elisabete Amaral ; Montenegro, Raquel Carvalho
Publisher:Basel: MDPI AG
Journal title:Pharmaceutics, 2022-09, Vol.14 (9), p.1841
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Comprehensive characterization of the Published Kinase Inhibitor Set
Author / Creator:Elkins, Jonathan M ; Fedele, Vita ; Szklarz, Marta ; Abdul Azeez, Kamal R ; Salah, Eidarus ; Mikolajczyk, Jowita ; Romanov, Sergei ; Sepetov, Nikolai ; Huang, Xi-Ping ; Roth, Bryan L ; Al Haj Zen, Ayman ; Fourches, Denis ; Muratov, Eugene ; Tropsha, Alex ; Morris, Joel ; Teicher, Beverly A ; Kunkel, Mark ; Polley, Eric ; Lackey, Karen E ; Atkinson, Francis L ; Overington, John P ; Bamborough, Paul ; Müller, Susanne ; Price, Daniel J ; Willson, Timothy M ; Drewry, David H ; Knapp, Stefan ; Zuercher, William J
Publisher:London: Nature Publishing Group UK
Journal title:Nature biotechnology, 2016-01, Vol.34 (1), p.95-103
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Progress towards a public chemogenomic set for protein kinases and a call for contributions
Author / Creator:Drewry, David H. ; Wells, Carrow I. ; Andrews, David M. ; Angell, Richard ; Al-Ali, Hassan ; Axtman, Alison D. ; Capuzzi, Stephen J. ; Elkins, Jonathan M. ; Ettmayer, Peter ; Frederiksen, Mathias ; Gileadi, Opher ; Gray, Nathanael ; Hooper, Alice ; Knapp, Stefan ; Laufer, Stefan ; Luecking, Ulrich ; Michaelides, Michael ; Müller, Susanne ; Muratov, Eugene ; Denny, R. Aldrin ; Saikatendu, Kumar S. ; Treiber, Daniel K. ; Zuercher, William J. ; Willson, Timothy M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-08, Vol.12 (8), p.e0181585-e0181585
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ArticlesPeer ReviewedFull Text
RIOK2: straddling the kinase/ATPase line
Author / Creator:Asquith, Christopher R. M. ; East, Michael P. ; Zuercher, William J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2019-07, Vol.18 (8), p.574-574
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Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor
Author / Creator:Zhang, Cunyu ; Creech, Katrina L. ; Zuercher, William J. ; Willson, Timothy M.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-07, Vol.9 (1), p.9982-9, Article 9982
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The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Author / Creator:Wells, Carrow I. ; Al-Ali, Hassan ; Andrews, David M. ; Asquith, Christopher R. M. ; Axtman, Alison D. ; Dikic, Ivan ; Ebner, Daniel ; Ettmayer, Peter ; Fischer, Christian ; Frederiksen, Mathias ; Futrell, Robert E. ; Gray, Nathanael S. ; Hatch, Stephanie B. ; Knapp, Stefan ; Lücking, Ulrich ; Michaelides, Michael ; Mills, Caitlin E. ; Müller, Susanne ; Owen, Dafydd ; Picado, Alfredo ; Saikatendu, Kumar S. ; Schröder, Martin ; Stolz, Alexandra ; Tellechea, Mariana ; Turunen, Brandon J. ; Vilar, Santiago ; Wang, Jinhua ; Zuercher, William J. ; Willson, Timothy M. ; Drewry, David H.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-01, Vol.22 (2), p.566
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ArticlesPeer ReviewedFull Text
A public-private partnership to unlock the untargeted kinome
Author / Creator:Knapp, Stefan ; Arruda, Paulo ; Blagg, Julian ; Burley, Stephen ; Drewry, David H ; Edwards, Aled ; Fabbro, Doriano ; Gillespie, Paul ; Gray, Nathanael S ; Kuster, Bernhard ; Lackey, Karen E ; Mazzafera, Paulo ; Tomkinson, Nicholas C O ; Willson, Timothy M ; Workman, Paul ; Zuercher, William J
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2013-01, Vol.9 (1), p.3-6
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Showing 1 to 20 of 52 results

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CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

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Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

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Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays

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Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

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New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

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In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors

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Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni

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Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data

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Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

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Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

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Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes

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Kinase Inhibitor Screening Displayed ALK as a Possible Therapeutic Biomarker for Gastric Cancer

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Comprehensive characterization of the Published Kinase Inhibitor Set

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Progress towards a public chemogenomic set for protein kinases and a call for contributions

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RIOK2: straddling the kinase/ATPase line

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Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor

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The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

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A public-private partnership to unlock the untargeted kinome

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