Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict the existence of a mechanostat that links strain induced by mechanical forces to skeletal remodeling. However, how the mechanostat influences bone remodeling remains elusive. Here, we find that
Piezo1
deficien...
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Full title
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
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TN_cdi_doaj_primary_oai_doaj_org_article_d37c4da320be48d0aad1955eb3259e3c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d37c4da320be48d0aad1955eb3259e3c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14146-6
