A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells
A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells
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Author / Creator
Funnell, Simon G. P. , Afrough, Babak , Baczenas, John James , Berry, Neil , Bewley, Kevin R. , Bradford, Rebecca , Florence, Clint , Duff, Yann Le , Lewis, Mark , Moriarty, Ryan V. , Connor, Shelby L. O. , Osman, Karen L. , Pullan, Steven , Rashid, Sujatha , Richards, Kevin S. , Stemple, Kimberly J. and Knezevic, Ivana
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
An array of SARS-CoV-2 virus variants have been isolated, propagated and used in in vitro assays, in vivo animal studies and human clinical trials. Observations of working stocks of SARS-CoV-2 suggest that sequential propagation in Vero cells leads to critical changes in the region of the furin cleavage site, which significantly reduce the value of...
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Full title
A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells
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TN_cdi_doaj_primary_oai_doaj_org_article_d3e61c501c474ee4bce5627f7aeb9067
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d3e61c501c474ee4bce5627f7aeb9067
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ISSN
2059-0105
E-ISSN
2059-0105
DOI
10.1038/s41541-021-00346-z
