Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
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Author / Creator
Zhang, Yanan , Wang, Jiancheng , Huang, Weijun , Cai, Jianye , Ba, Junhui , Wang, Yi , Ke, Qiong , Huang, Yinong , Liu, Xin , Qiu, Yuan , Lu, Qiying , Sui, Xin , Shi, Yue , Wang, Tao , Shen, Huiyong , Guan, Yuanjun , Zhou, Ying , Chen, Yuan , Wang, Maosheng and Xiang, Andy Peng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Emerging evidence has revealed that Nestin not only serves as a biomarker for multipotent stem cells, but also regulates cell proliferation and invasion in various tumors. However, the mechanistic contributions of Nestin to cancer pathogenesis are still unknown. In the present study, previously thought to reside exclusively in the cytoplasm, Nestin...
Alternative Titles
Full title
Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
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TN_cdi_doaj_primary_oai_doaj_org_article_d48c676e77354d918de1fbd1372346c0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d48c676e77354d918de1fbd1372346c0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05808-y
