Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
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Author / Creator
Zhang, Haiyang , Deng, Ting , Liu, Rui , Bai, Ming , Zhou, Likun , Wang, Xia , Li, Shuang , Wang, Xinyi , Yang, Haiou , Li, Jialu , Ning, Tao , Huang, Dingzhi , Li, Hongli , Zhang, Le , Ying, Guoguang and Ba, Yi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The metastatic organotropism has been one of the cancer’s greatest mysteries since the ‘seed and soil’ hypothesis. Although the role of EGFR in cancer cells is well studied, the effects of secreted EGFR transported by exosomes are less understood. Here we show that EGFR in exosomes secreted from gastric cancer cells can be delivered into the liver...
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Full title
Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_d4d3d21a7c36464a8fb02e163d543374
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d4d3d21a7c36464a8fb02e163d543374
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15016
