Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite the fact that many centromere proteins were discovered in patients with SSc. Here we report that lesion skin fibroblasts from SSc patients show marked alterations in centromeric DNA. SSc fibroblasts also show DNA damage, abnormal chromosome segregation, aneuploidy (only...
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Full title
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_d5eaf6cdd6504e8d8ebc8070af2ffb48
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d5eaf6cdd6504e8d8ebc8070af2ffb48
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34775-8
