689 ATRC-101 Drives Potent Single-Agent Activity in Mouse Syngeneic Tumor Models via a Novel Cellula...
689 ATRC-101 Drives Potent Single-Agent Activity in Mouse Syngeneic Tumor Models via a Novel Cellular Mechanism of Action
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Author / Creator
Leung, Yvonne , Vad, Nikhil , Ye, Anne , Santos, Daniel , Cao, Wei , Czupalla, Cathrin , Vivian, John , Williams, Carlene , Sapugay, Judevin , Harbell, Michael , Lippow, Shaun , Carroll, Chantia , Kates, Lance , Haugen, Benjamin , Bolton, Gary , Armanini, Mark , Aydin, Iraz , Whidden, Mark , Velasco-Delgado, Mauricio , Chu, Felix , Wechsler, Erin , Nguyen, Ngan , Robinson, William , Serafini, Tito , Emerling, Daniel , Greenberg, Norman , Manning-Bog, Amy and Scholz, Alexander
Publisher
London: BMJ Publishing Group LTD
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Language
English
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Publisher
London: BMJ Publishing Group LTD
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More information
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Contents
BackgroundWe have previously demonstrated adaptive antibody responses targeting public tumor antigens in cancer patients. ATRC-101, a clinical stage, engineered version of an antibody identified in such a patient, displays robust single-agent activity in syngeneic tumor models requiring Fc receptors (FcRs) expressed by innate immune cells and the p...
Alternative Titles
Full title
689 ATRC-101 Drives Potent Single-Agent Activity in Mouse Syngeneic Tumor Models via a Novel Cellular Mechanism of Action
Authors, Artists and Contributors
Author / Creator
Vad, Nikhil
Ye, Anne
Santos, Daniel
Cao, Wei
Czupalla, Cathrin
Vivian, John
Williams, Carlene
Sapugay, Judevin
Harbell, Michael
Lippow, Shaun
Carroll, Chantia
Kates, Lance
Haugen, Benjamin
Bolton, Gary
Armanini, Mark
Aydin, Iraz
Whidden, Mark
Velasco-Delgado, Mauricio
Chu, Felix
Wechsler, Erin
Nguyen, Ngan
Robinson, William
Serafini, Tito
Emerling, Daniel
Greenberg, Norman
Manning-Bog, Amy
Scholz, Alexander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d68b61ac36ac49e5b4d60c03de821131
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d68b61ac36ac49e5b4d60c03de821131
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-SITC2020.0689
