Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐lab...
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
About this item
Full title
Author / Creator
Delaunois, Annie , Abernathy, Matthew , Anderson, Warren D. , Beattie, Kylie A. , Chaudhary, Khuram W. , Coulot, Julie , Gryshkova, Vitalina , Hebeisen, Simon , Holbrook, Mark , Kramer, James , Kuryshev, Yuri , Leishman, Derek , Lushbough, Isabel , Passini, Elisa , Redfern, Will S. , Rodriguez, Blanca , Rossman, Eric I. , Trovato, Cristian , Wu, Caiyun and Valentin, Jean‐Pierre
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine (OH‐CLQ)‐mediated QT prolongation and Torsades de Pointes (TdP), alone and combined with erythromycin (ERT) and azithromycin (AZI), drugs repurposed during th...
Alternative Titles
Full title
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
Authors, Artists and Contributors
Author / Creator
Abernathy, Matthew
Anderson, Warren D.
Beattie, Kylie A.
Chaudhary, Khuram W.
Coulot, Julie
Gryshkova, Vitalina
Hebeisen, Simon
Holbrook, Mark
Kramer, James
Kuryshev, Yuri
Leishman, Derek
Lushbough, Isabel
Passini, Elisa
Redfern, Will S.
Rodriguez, Blanca
Rossman, Eric I.
Trovato, Cristian
Wu, Caiyun
Valentin, Jean‐Pierre
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d703d6568c29415c8e2d93ccf47af5d0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d703d6568c29415c8e2d93ccf47af5d0
Other Identifiers
ISSN
1752-8054
E-ISSN
1752-8062
DOI
10.1111/cts.13011
