Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
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Author / Creator
Kurniansyah, Nuzulul , Goodman, Matthew O. , Khan, Alyna T. , Wang, Jiongming , Feofanova, Elena , Bis, Joshua C. , Wiggins, Kerri L. , Huffman, Jennifer E. , Kelly, Tanika , Elfassy, Tali , Guo, Xiuqing , Palmas, Walter , Lin, Henry J. , Hwang, Shih-Jen , Gao, Yan , Young, Kendra , Kinney, Gregory L. , Smith, Jennifer A. , Yu, Bing , Liu, Simin , Wassertheil-Smoller, Sylvia , Manson, JoAnn E. , Zhu, Xiaofeng , Chen, Yii-Der Ida , Lee, I-Te , Gu, C. Charles , Lloyd-Jones, Donald M. , Zöllner, Sebastian , Fornage, Myriam , Kooperberg, Charles , Correa, Adolfo , Psaty, Bruce M. , Arnett, Donna K. , Isasi, Carmen R. , Rich, Stephen S. , Kaplan, Robert C. , Redline, Susan , Mitchell, Braxton D. , Franceschini, Nora , Levy, Daniel , Rotter, Jerome I. , Morrison, Alanna C. and Sofer, Tamar
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare “clumping-and-thresholding” (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, includin...
Alternative Titles
Full title
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
Authors, Artists and Contributors
Author / Creator
Goodman, Matthew O.
Khan, Alyna T.
Wang, Jiongming
Feofanova, Elena
Bis, Joshua C.
Wiggins, Kerri L.
Huffman, Jennifer E.
Kelly, Tanika
Elfassy, Tali
Guo, Xiuqing
Palmas, Walter
Lin, Henry J.
Hwang, Shih-Jen
Gao, Yan
Young, Kendra
Kinney, Gregory L.
Smith, Jennifer A.
Yu, Bing
Liu, Simin
Wassertheil-Smoller, Sylvia
Manson, JoAnn E.
Zhu, Xiaofeng
Chen, Yii-Der Ida
Lee, I-Te
Gu, C. Charles
Lloyd-Jones, Donald M.
Zöllner, Sebastian
Fornage, Myriam
Kooperberg, Charles
Correa, Adolfo
Psaty, Bruce M.
Arnett, Donna K.
Isasi, Carmen R.
Rich, Stephen S.
Kaplan, Robert C.
Redline, Susan
Mitchell, Braxton D.
Franceschini, Nora
Levy, Daniel
Rotter, Jerome I.
Morrison, Alanna C.
Sofer, Tamar
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d721f599909e48e7aa862786e05f3dd9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d721f599909e48e7aa862786e05f3dd9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-38990-9
