ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Signs of proteostasis failure often entwine with those of metabolic stress at the cellular level. Here, we study protein sequestration during glucose deprivation-induced ATP decline in
Saccharomyces cerevisiae
. Using live-cell imaging, we find that sequestration of misfolded proteins and nascent polypeptides into two distinct compartments, s...
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ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_d7329f06ba3b4892a2f5791afd48223e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d7329f06ba3b4892a2f5791afd48223e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19104-1