Structural insights into TSC complex assembly and GAP activity on Rheb
Structural insights into TSC complex assembly and GAP activity on Rheb
About this item
Full title
Author / Creator
Yang, Huirong , Yu, Zishuo , Chen, Xizi , Li, Jiabei , Li, Ningning , Cheng, Jiaxuan , Gao, Ning , Yuan, Hai-Xin , Ye, Dan , Guan, Kun-Liang and Xu, Yanhui
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC complex functions as a GTPase-activating protein (GAP) towards small GTPase Rheb and inhibits Rheb-mediated activation of mTORC1. Mutations in
TSC
genes cause tuberous sclerosis. In this study, the near-atomic reso...
Alternative Titles
Full title
Structural insights into TSC complex assembly and GAP activity on Rheb
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d745e4d05ea7420aab143072e24bf771
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d745e4d05ea7420aab143072e24bf771
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20522-4
