A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway
A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway
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Publisher
London, England: SAGE Publications
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Language
English
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Publisher
London, England: SAGE Publications
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Contents
A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune response via activation of NF-κB and IRF3. Nevertheless, mechanisms governing TLR3 regulation remain poorly...
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Full title
A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_d8149479e43e41288954e39bd1f60b79
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d8149479e43e41288954e39bd1f60b79
Other Identifiers
ISSN
1753-4259
E-ISSN
1753-4267
DOI
10.1177/1753425920915507
