An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
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Full title
Author / Creator
Liu, Lei , Tao, Tianyu , Liu, Shihua , Yang, Xia , Chen, Xuwei , Liang, Jiaer , Hong, Ruohui , Wang, Wenting , Yang, Yi , Li, Xiaoyi , Zhang, Youhong , Li, Quanfeng , Liang, Shujun , Yu, Haocheng , Wu, Yun , Guo, Xinyu , Lai, Yan , Ding, Xiaofan , Guan, Hongyu , Wu, Jueheng , Zhu, Xun , Yuan, Jie , Li, Jun , Su, Shicheng , Li, Mengfeng , Cai, Xiuyu , Cai, Junchao and Tian, Han
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how Notch signaling is overactivated to couple tumor metastasis and self-renewal in NSCLC cells, we performed the current study and showed that RFC4, a DNA replication factor amplified in more than 40% of NSCLC tissues, directly binds to the Notch1 in...
Alternative Titles
Full title
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
Authors, Artists and Contributors
Author / Creator
Tao, Tianyu
Liu, Shihua
Yang, Xia
Chen, Xuwei
Liang, Jiaer
Hong, Ruohui
Wang, Wenting
Yang, Yi
Li, Xiaoyi
Zhang, Youhong
Li, Quanfeng
Liang, Shujun
Yu, Haocheng
Wu, Yun
Guo, Xinyu
Lai, Yan
Ding, Xiaofan
Guan, Hongyu
Wu, Jueheng
Zhu, Xun
Yuan, Jie
Li, Jun
Su, Shicheng
Li, Mengfeng
Cai, Xiuyu
Cai, Junchao
Tian, Han
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_d91f2bc20dee437894291254ef20f4fc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d91f2bc20dee437894291254ef20f4fc
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22971-x
