High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and...
High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Here, we examined the potential role of mitochondrial DNA (mtDNA) levels in conveying aggressive phenotypes in cancer cells, using two widely-used breast cell lines as model systems (MCF7[ER+] and MDA-MB-231[ER-]). These human breast cancer cell lines were fractionated into mtDNA-high and mtDNA-low cell sub-populations by flow cytometry, using SYBR...
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High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_d958f5e76ee84067bc0ca9f7782ac59c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_d958f5e76ee84067bc0ca9f7782ac59c
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-07103-9
