Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
About this item
Full title
Author / Creator
Al-Ramahi, Ismael , Giridharan, Sai Srinivas Panapakkam , Chen, Yu-Chi , Patnaik, Samarjit , Safren, Nathaniel , Hasegawa, Junya , de Haro, Maria , Wagner Gee, Amanda K , Titus, Steven A , Jeong, Hyunkyung , Clarke, Jonathan , Krainc, Dimitri , Zheng, Wei , Irvine, Robin F , Barmada, Sami , Ferrer, Marc , Southall, Noel , Weisman, Lois S , Botas, Juan and Marugan, Juan Jose
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Sciences Publications Ltd
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Scope and Contents
Contents
The discovery of the causative gene for Huntington’s disease (HD) has promoted numerous efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and potentially forestall the appearance of HD-related neurological defects. Using a cell-based model of pathogenic huntingtin expression, we identified a class of compoun...
Alternative Titles
Full title
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
Authors, Artists and Contributors
Author / Creator
Giridharan, Sai Srinivas Panapakkam
Chen, Yu-Chi
Patnaik, Samarjit
Safren, Nathaniel
Hasegawa, Junya
de Haro, Maria
Wagner Gee, Amanda K
Titus, Steven A
Jeong, Hyunkyung
Clarke, Jonathan
Krainc, Dimitri
Zheng, Wei
Irvine, Robin F
Barmada, Sami
Ferrer, Marc
Southall, Noel
Weisman, Lois S
Botas, Juan
Marugan, Juan Jose
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_da11075a98b347ab84cdded4b0780b44
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_da11075a98b347ab84cdded4b0780b44
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.29123
