Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Filaments made of residues 120-254 of transmembrane protein 106B (TMEM106B) form in an age-dependent manner and can be extracted from the brains of neurologically normal individuals and those of subjects with a variety of neurodegenerative diseases. TMEM106B filament formation requires cleavage at residue 120 of the 274 amino acid protein; at prese...
Alternative Titles
Full title
Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_db92f0d916014e6583ce491ec51339dd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_db92f0d916014e6583ce491ec51339dd
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-024-01813-z
