ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzyme...
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
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Author / Creator
Wei, Juncheng , Yuan, Yanzhi , Chen, Lu , Xu, Yuanming , Zhang, Yuehui , Wang, Yajun , Yang, Yanjie , Peek, Clara Bien , Diebold, Lauren , Yang, Yi , Gao, Beixue , Jin, Chaozhi , Melo-Cardenas, Johanna , Chandel, Navdeep S. , Zhang, Donna D. , Pan, Hui , Zhang, Kezhong , Wang, Jian , He, Fuchu and Fang, Deyu
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The HMG-CoA reductase degradation protein 1 (HRD1) has been identified as a key enzyme for endoplasmic reticulum-associated degradation of misfolded proteins, but its organ-specific physiological functions remain largely undefined. Here we show that mice with HRD1 deletion specifically in the liver display increased energy expenditure and are resis...
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Full title
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dbba9017edc14c20b4a2be08a43dd76f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dbba9017edc14c20b4a2be08a43dd76f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06091-7
