Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular...
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level
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Author / Creator
Coutandin, Daniel , Osterburg, Christian , Srivastav, Ratnesh Kumar , Sumyk, Manuela , Kehrloesser, Sebastian , Gebel, Jakob , Tuppi, Marcel , Hannewald, Jens , Schäfer, Birgit , Salah, Eidarus , Mathea, Sebastian , Müller-Kuller, Uta , Doutch, James , Grez, Manuel , Knapp, Stefan and Dötsch, Volker
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. TAp63α is kept in an inactive and exclusively dimeric state but undergoes rapid phosphorylation-induced tetramerization and concomit...
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Full title
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level
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TN_cdi_doaj_primary_oai_doaj_org_article_dbeb5b0472134bb4993b7f21d2d2f81c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dbeb5b0472134bb4993b7f21d2d2f81c
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.13909
