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ArticlesPeer ReviewedFull Text
Retroviral gene therapy in Germany with a view on previous experience and future perspectives
Author / Creator:Morgan, Michael A. ; Galla, Melanie ; Grez, Manuel ; Fehse, Boris ; Schambach, Axel
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2021-09, Vol.28 (9), p.494-512
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Gene therapy on the move
Author / Creator:Kaufmann, Kerstin B. ; Büning, Hildegard ; Galy, Anne ; Schambach, Axel ; Grez, Manuel
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2013-11, Vol.5 (11), p.1642-1661
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Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor
Author / Creator:Schönfeld, Kurt ; Sahm, Christiane ; Zhang, Congcong ; Naundorf, Sonja ; Brendel, Christian ; Odendahl, Marcus ; Nowakowska, Paulina ; Bönig, Halvard ; Köhl, Ulrike ; Kloess, Stephan ; Köhler, Sylvia ; Holtgreve-Grez, Heidi ; Jauch, Anna ; Schmidt, Manfred ; Schubert, Ralf ; Kühlcke, Klaus ; Seifried, Erhard ; Klingemann, Hans G ; Rieger, Michael A ; Tonn, Torsten ; Grez, Manuel ; Wels, Winfried S
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2015-02, Vol.23 (2), p.330-338
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Gene Therapy of Chronic Granulomatous Disease: The Engraftment Dilemma
Author / Creator:Grez, Manuel ; Reichenbach, Janine ; Schwäble, Joachim ; Seger, Reinhard ; Dinauer, Mary C ; Thrasher, Adrian J
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2011-01, Vol.19 (1), p.28-35
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Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level
Author / Creator:Coutandin, Daniel ; Osterburg, Christian ; Srivastav, Ratnesh Kumar ; Sumyk, Manuela ; Kehrloesser, Sebastian ; Gebel, Jakob ; Tuppi, Marcel ; Hannewald, Jens ; Schäfer, Birgit ; Salah, Eidarus ; Mathea, Sebastian ; Müller-Kuller, Uta ; Doutch, James ; Grez, Manuel ; Knapp, Stefan ; Dötsch, Volker
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2016-03, Vol.5
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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
Author / Creator:Ott, Marion G ; Schmidt, Manfred ; Schwarzwaelder, Kerstin ; Stein, Stefan ; Siler, Ulrich ; Koehl, Ulrike ; Glimm, Hanno ; Kühlcke, Klaus ; Schilz, Andrea ; Kunkel, Hana ; Naundorf, Sonja ; Brinkmann, Andrea ; Deichmann, Annette ; Fischer, Marlene ; Ball, Claudia ; Pilz, Ingo ; Dunbar, Cynthia ; Du, Yang ; Jenkins, Nancy A ; Copeland, Neal G ; Lüthi, Ursula ; Hassan, Moustapha ; Thrasher, Adrian J ; Hoelzer, Dieter ; von Kalle, Christof ; Seger, Reinhard ; Grez, Manuel
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2006-04, Vol.12 (4), p.401-409
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Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity
Author / Creator:Suerth, Julia D ; Maetzig, Tobias ; Brugman, Martijn H ; Heinz, Niels ; Appelt, Jens-Uwe ; Kaufmann, Kerstin B ; Schmidt, Manfred ; Grez, Manuel ; Modlich, Ute ; Baum, Christopher ; Schambach, Axel
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2012-05, Vol.20 (5), p.1022-1032
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MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO
Author / Creator:Kohrs, Nicole ; Kolodziej, Stephan ; Kuvardina, Olga N ; Herglotz, Julia ; Yillah, Jasmin ; Herkt, Stefanie ; Piechatzek, Alexander ; Salinas Riester, Gabriela ; Lingner, Thomas ; Wichmann, Christian ; Bonig, Halvard ; Seifried, Erhard ; Platzbecker, Uwe ; Medyouf, Hind ; Grez, Manuel ; Lausen, Jörn
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2016-03, Vol.12 (3), p.e1005946-e1005946
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Alpharetroviral Vector-mediated Gene Therapy for X-CGD: Functional Correction and Lack of Aberrant Splicing
Author / Creator:Kaufmann, Kerstin B. ; Brendel, Christian ; Suerth, Julia D. ; Mueller-Kuller, Uta ; Chen-Wichmann, Linping ; Schwäble, Joachim ; Pahujani, Shweta ; Kunkel, Hana ; Schambach, Axel ; Baum, Christopher ; Grez, Manuel
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2013-03, Vol.21 (3), p.648-661
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Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay
Author / Creator:Ochs, Meike J ; Sorg, Bernd L ; Pufahl, Laura ; Grez, Manuel ; Suess, Beatrix ; Steinhilber, Dieter
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-02, Vol.7 (2), p.e31363
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Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD
Author / Creator:Vets, Sofie ; De Rijck, Jan ; Brendel, Christian ; Grez, Manuel ; Bushman, Frederic ; Debyser, Zeger ; Gijsbers, Rik
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2013-03, Vol.2 (3), p.e77-e77, Article e77
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High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies
Author / Creator:Giordano, Frank A ; Appelt, Jens-Uwe ; Link, Barbara ; Gerdes, Sebastian ; Lehrer, Christina ; Scholz, Simone ; Paruzynski, Anna ; Roeder, Ingo ; Wenz, Frederik ; Glimm, Hanno ; von Kalle, Christof ; Grez, Manuel ; Schmidt, Manfred ; Laufs, Stephanie
Publisher:United States: Elsevier Limited
Journal title:Molecular therapy. Methods & clinical development, 2015-01, Vol.2, p.14061-14061, Article 14061
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Generation of X-CGD cells for vector evaluation from healthy donor CD34+ HSCs by shRNA-mediated knock down of gp91phox
Author / Creator:Brendel, Christian ; Kaufmann, Kerstin B ; Krattenmacher, Anja ; Pahujani, Shweta ; Grez, Manuel
Publisher:Milwaukee: Elsevier Limited
Journal title:Molecular therapy. Methods & clinical development, 2014-01, Vol.1 (C), p.14037, Article 14037
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Lentiviral gene therapy for X-linked chronic granulomatous disease
Author / Creator:Kohn, Donald B. ; Booth, Claire ; Kang, Elizabeth M. ; Pai, Sung-Yun ; Shaw, Kit L. ; Santilli, Giorgia ; Armant, Myriam ; Buckland, Karen F. ; Choi, Uimook ; De Ravin, Suk See ; Dorsey, Morna J. ; Kuo, Caroline Y. ; Leon-Rico, Diego ; Rivat, Christine ; Izotova, Natalia ; Gilmour, Kimberly ; Snell, Katie ; Dip, Jinhua Xu-Bayford ; Darwish, Jinan ; Morris, Emma C. ; Terrazas, Dayna ; Wang, Leo D. ; Bauser, Christopher A. ; Paprotka, Tobias ; Kuhns, Douglas B. ; Gregg, John ; Raymond, Hayley E. ; Everett, John K. ; Honnet, Geraldine ; Biasco, Luca ; Newburger, Peter E. ; Bushman, Frederic D. ; Grez, Manuel ; Gaspar, H. Bobby ; Williams, David A. ; Malech, Harry L. ; Galy, Anne ; Thrasher, Adrian J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature Medicine, 2020-02, Vol.26 (2), p.200-206
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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
Author / Creator:Stein, Stefan ; Ott, Marion G ; Schultze-Strasser, Stephan ; Jauch, Anna ; Burwinkel, Barbara ; Kinner, Andrea ; Schmidt, Manfred ; Krämer, Alwin ; Schwäble, Joachim ; Glimm, Hanno ; Koehl, Ulrike ; Preiss, Carolin ; Ball, Claudia ; Martin, Hans ; Göhring, Gudrun ; Schwarzwaelder, Kerstin ; Hofmann, Wolf-Karsten ; Karakaya, Kadin ; Tchatchou, Sandrine ; Yang, Rongxi ; Reinecke, Petra ; Kühlcke, Klaus ; Schlegelberger, Brigitte ; Thrasher, Adrian J ; Hoelzer, Dieter ; Seger, Reinhard ; von Kalle, Christof ; Grez, Manuel
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2010-02, Vol.16 (2), p.198-204
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Optimization and antiviral analysis of peptide ligands for the HIV-1 packaging signal PSI
Author / Creator:Dietz, Julia ; Pustowka, Anette ; Kaur, Ajit ; Koch, Joachim ; Mensch, Sarah ; Stein, Stefan ; Grez, Manuel ; Divita, Gilles ; Mély, Yves ; Schwalbe, Harald ; Dietrich, Ursula
Publisher:London: BioMed Central Ltd
Journal title:Retrovirology, 2006-12, Vol.3 (S1), p.S58-S58, Article S58
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Targeted Cell Entry of Lentiviral Vectors
Author / Creator:Funke, Sabrina ; Maisner, Andrea ; Mühlebach, Michael D ; Koehl, Ulrike ; Grez, Manuel ; Cattaneo, Roberto ; Cichutek, Klaus ; Buchholz, Christian J
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2008-08, Vol.16 (8), p.1427-1436
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An Improved Bicistronic CD20/tCD34 Vector for Efficient Purification and In Vivo Depletion of Gene-Modified T Cells for Adoptive Immunotherapy
Author / Creator:Vogler, Isabel ; Newrzela, Sebastian ; Hartmann, Sylvia ; Schneider, Nadine ; von Laer, Dorothee ; Koehl, Ulrike ; Grez, Manuel
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2010-07, Vol.18 (7), p.1330-1338
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Biochemical Correction of X-CGD by a Novel Chimeric Promoter Regulating High Levels of Transgene Expression in Myeloid Cells
Author / Creator:Santilli, Giorgia ; Almarza, Elena ; Brendel, Christian ; Choi, Uimook ; Beilin, Chiara ; Blundell, Michael P ; Haria, Sneha ; Parsley, Kathryn L ; Kinnon, Christine ; Malech, Harry L ; Bueren, Juan A ; Grez, Manuel ; Thrasher, Adrian J
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2011-01, Vol.19 (1), p.122-132
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Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis
Author / Creator:Chiriaco, Maria ; Farinelli, Giada ; Capo, Valentina ; Zonari, Erika ; Scaramuzza, Samantha ; Di Matteo, Gigliola ; Sergi, Lucia Sergi ; Migliavacca, Maddalena ; Hernandez, Raisa Jofra ; Bombelli, Ferdinando ; Giorda, Ezio ; Kajaste-Rudnitski, Anna ; Trono, Didier ; Grez, Manuel ; Rossi, Paolo ; Finocchi, Andrea ; Naldini, Luigi ; Gentner, Bernhard ; Aiuti, Alessandro
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2014-08, Vol.22 (8), p.1472-1483
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Showing 1 to 20 of 46 results

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Retroviral gene therapy in Germany with a view on previous experience and future perspectives

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Gene therapy on the move

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Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor

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Gene Therapy of Chronic Granulomatous Disease: The Engraftment Dilemma

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Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1

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Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

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MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO

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Alpharetroviral Vector-mediated Gene Therapy for X-CGD: Functional Correction and Lack of Aberrant Splicing

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Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay

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Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

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High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

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Generation of X-CGD cells for vector evaluation from healthy donor CD34+ HSCs by shRNA-mediated knock down of gp91phox

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Lentiviral gene therapy for X-linked chronic granulomatous disease

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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

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Optimization and antiviral analysis of peptide ligands for the HIV-1 packaging signal PSI

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Targeted Cell Entry of Lentiviral Vectors

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An Improved Bicistronic CD20/tCD34 Vector for Efficient Purification and In Vivo Depletion of Gene-Modified T Cells for Adoptive Immunotherapy

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Biochemical Correction of X-CGD by a Novel Chimeric Promoter Regulating High Levels of Transgene Expression in Myeloid Cells

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Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis

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