Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation
Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Preneoplastic mammary tissues from human female
BRCA1
mutation carriers, or
Brca1
-mutant mice, display unexplained abnormalities in luminal differentiation. We now study the division characteristics of human mammary cells purified from female
BRCA1
mutation carriers or non-carrier donors. We show primary
BRCA1
mutant/+ cell...
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Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation
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TN_cdi_doaj_primary_oai_doaj_org_article_dc008dd191494a1c87bda1b62ace4d8c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dc008dd191494a1c87bda1b62ace4d8c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29885-2