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Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dc008dd191494a1c87bda1b62ace4d8c

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

About this item

Full title

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2022-04, Vol.13 (1), p.2200-17, Article 2200

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Preneoplastic mammary tissues from human female
BRCA1
mutation carriers, or
Brca1
-mutant mice, display unexplained abnormalities in luminal differentiation. We now study the division characteristics of human mammary cells purified from female
BRCA1
mutation carriers or non-carrier donors. We show primary
BRCA1
mutant/+ cell...

Alternative Titles

Full title

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_dc008dd191494a1c87bda1b62ace4d8c

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dc008dd191494a1c87bda1b62ace4d8c

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-022-29885-2

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