Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pa...
Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease. In order to develop effective AD therapies, it is critical to identify the strains of Aβ that might arise prior to...
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Full title
Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
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TN_cdi_doaj_primary_oai_doaj_org_article_dce996dec328498197f03187eecb924c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dce996dec328498197f03187eecb924c
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01298-0
