Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress th...
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
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Author / Creator
Limbocker, Ryan , Staats, Roxine , Chia, Sean , Ruggeri, Francesco S , Mannini, Benedetta , Xu, Catherine K , Perni, Michele , Cascella, Roberta , Bigi, Alessandra , Sasser, Liam R , Block, Natalie R , Wright, Aidan K , Kreiser, Ryan P , Custy, Edward T , Meisl, Georg , Errico, Silvia , Habchi, Johnny , Flagmeier, Patrick , Kartanas, Tadas , Hollows, Jared E , Nguyen, Lam T , LeForte, Kathleen , Barbut, Denise , Kumita, Janet R , Cecchi, Cristina , Zasloff, Michael , Knowles, Tuomas P J , Dobson, Christopher M , Chiti, Fabrizio and Vendruscolo, Michele
Publisher
Switzerland: Frontiers Research Foundation
Journal title
Language
English
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Publisher
Switzerland: Frontiers Research Foundation
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More information
Scope and Contents
Contents
The aberrant aggregation of proteins is a key molecular event in the development and progression of a wide range of neurodegenerative disorders. We have shown previously that squalamine and trodusquemine, two natural products in the aminosterol class, can modulate the aggregation of the amyloid-β peptide (Aβ) and of α-synuclein (αS), which are asso...
Alternative Titles
Full title
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
Authors, Artists and Contributors
Author / Creator
Staats, Roxine
Chia, Sean
Ruggeri, Francesco S
Mannini, Benedetta
Xu, Catherine K
Perni, Michele
Cascella, Roberta
Bigi, Alessandra
Sasser, Liam R
Block, Natalie R
Wright, Aidan K
Kreiser, Ryan P
Custy, Edward T
Meisl, Georg
Errico, Silvia
Habchi, Johnny
Flagmeier, Patrick
Kartanas, Tadas
Hollows, Jared E
Nguyen, Lam T
LeForte, Kathleen
Barbut, Denise
Kumita, Janet R
Cecchi, Cristina
Zasloff, Michael
Knowles, Tuomas P J
Dobson, Christopher M
Chiti, Fabrizio
Vendruscolo, Michele
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TN_cdi_doaj_primary_oai_doaj_org_article_dd03b8d056964d40bab6c08d74df6acb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd03b8d056964d40bab6c08d74df6acb
Other Identifiers
ISSN
1662-4548,1662-453X
E-ISSN
1662-453X
DOI
10.3389/fnins.2021.680026
