Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor,...
Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses
About this item
Full title
Author / Creator
Thaler, Melissa , Ofman, Tim P. , Kok, Ken , Heming, Jurriaan J. A. , Moran, Elisha , Pickles, Isabelle , Leijs, Anouk A. , van den Nieuwendijk, Adrianus M. C. H. , van den Berg, Richard J. B. H. N. , Ruijgrok, Gijs , Armstrong, Zachary , Salgado-Benvindo, Clarisse , Ninaber, Dennis K. , Snijder, Eric J. , van Boeckel, Constant A. A. , Artola, Marta , Davies, Gideon J. , Overkleeft, Herman S. and van Hemert, Martijn J.
Publisher
United States: American Chemical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Chemical Society
More information
Scope and Contents
Contents
The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER protein quality control. We found, by screening a panel of deoxynojirimycin and cyclitol glycomimetics, that the mechanism-based ER α-glucosidase II inhibitor, 1,6-epi-cyclophellitol cyclosu...
Alternative Titles
Full title
Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses
Authors, Artists and Contributors
Author / Creator
Ofman, Tim P.
Kok, Ken
Heming, Jurriaan J. A.
Moran, Elisha
Pickles, Isabelle
Leijs, Anouk A.
van den Nieuwendijk, Adrianus M. C. H.
van den Berg, Richard J. B. H. N.
Ruijgrok, Gijs
Armstrong, Zachary
Salgado-Benvindo, Clarisse
Ninaber, Dennis K.
Snijder, Eric J.
van Boeckel, Constant A. A.
Artola, Marta
Davies, Gideon J.
Overkleeft, Herman S.
van Hemert, Martijn J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dd42ac5e444a4e7ba47c0548b472ccb4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd42ac5e444a4e7ba47c0548b472ccb4
Other Identifiers
ISSN
2374-7943
E-ISSN
2374-7951
DOI
10.1021/acscentsci.4c00506
